Metformin Rx
A once-daily pill that may help the body use sugar more efficiently, support appetite control, and build a stronger metabolic foundation for long-term health.
- Improved insulin sensitivity
- Flatter glucose curves
- Decades of safety data
- Flexible monthly plans
- US-licensed pharmacies
- Clinician-guided dosing
- Pause or cancel anytime
Starting at$25 / mo
- HSA / FSA eligible
- Ongoing, expert support
- Free, discreet shipping
- 100% online
- Do I need diabetes to take it?
- No. We prescribe it off-label for insulin resistance and as part of longevity protocols. Your labs and history determine whether it's appropriate.
- Will it interfere with building muscle?
- Some studies suggest metformin can blunt certain training adaptations, particularly at higher doses. If hypertrophy is a primary goal, discuss dose and timing with your clinician.
- Why extended release?
- Almost entirely tolerability. The extended-release form causes considerably less GI upset at the same total daily dose.
GI upset — loose stools, bloating and cramping — is common in the first weeks and is substantially reduced by using the extended-release form and taking it with food. Persistent symptoms usually mean titrating more slowly.
Who this is not for
- Requires adequate kidney function; we check before prescribing
- Long-term use can lower B12 — we monitor and supplement
- May blunt some training adaptations at higher doses
- Must be held before procedures using iodinated contrast
Regulatory status: FDA-approved. Read our full medical disclaimer.
Disclaimer
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. This product is FDA-approved; some uses described on this page are off-label. Actual product packaging may appear differently than shown.
What is Metformin?
(met-FOR-min)
Metformin reduces hepatic glucose production — the liver's contribution to your fasting blood sugar — which is its primary and best-established action.
It activates AMPK, a cellular energy sensor that also mediates part of the benefit of exercise and caloric restriction.
Individual results vary. Figures shown are modelled from published literature and aggregated, self-reported member check-ins; they are illustrative and are not a guarantee of outcome. See the evidence tier for this treatment.
average reduction in fasting insulin
30%How Metformin works
Week 1
500 mg extended release with food. GI symptoms are most likely now and are the reason we start low.
30 Days
First increase if tolerated. Most patients report the initial GI effects have already faded.
3 Months
Repeat metabolic panel. Fasting insulin and HbA1c are the markers we expect to have moved.
6 Months
Kidney function and B12 checked, dose reviewed against results rather than habit.
1 Year and Beyond
Annual monitoring continues. Metformin is a long-horizon intervention and we treat it that way.
Our research is shaping what comes next
Most providers in this category focus on doing more. We study what happens when the goal is finding the right amount. With a fully in-house care team, longevity researchers, and 17+ protocols graded by evidence tier, we're built to support the bigger picture of your health.
Metformin as a tool to target aging (TAME rationale)
Cell Metabolism · 2016
Metformin and longevity in a diabetic cohort versus controls
Diabetes, Obesity and Metabolism · 2014
AMPK activation and the regulation of healthspan
Nature Metabolism · 2021
Metformin
treatment insights
Modelled response patterns are trending in the optimal range
Read our clinical trials
Longevity and longevity
Our researchers are studying metformin through a longevity-focused lens, exploring how lower-dose protocols may be used in long-horizon care beyond the primary indication.
Read our researchSubscribe & save
Care that starts
with you
$25/month
What's included
- Personalized, clinician-guided plan
- Flexible monthly plans
- Dispensed by a US-licensed pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Third-party potency and sterility testing
How it works
Choosing how you age starts here
- Certified1
Clinician-led
Connect with a clinician
Connect with one of our US-licensed, in-house medical providers with 199+ years of combined clinical experience to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Fast, discreet shipping
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed pharmacy, third-party tested by lot, and shipped to your door in unbranded packaging — cold-chain where the formulation requires it.
- 3
Ongoing support
Adjust as you go
Message your care team whenever something changes. Dose adjustments, side-effect questions and protocol changes are included in your membership — never another appointment, never another fee.
The protocol
- Starting dose
- 500 mg daily with food
- Target dose
- 500–1500 mg daily, extended release
- Titration
- Increase every 1–2 weeks
- Monitoring
- Kidney function and B12 annually
- Onset
- Metabolic changes within weeks
A good fit if
- Prediabetes or insulin resistance on labs
- A longevity protocol with a metabolic focus
- Family history of type 2 diabetes
- You want an intervention with real long-term human data
Worth knowing
- Requires adequate kidney function; we check before prescribing
- Long-term use can lower B12 — we monitor and supplement
- May blunt some training adaptations at higher doses
- Must be held before procedures using iodinated contrast
Ready when you are
Start Metformin today
Complete a ten-minute intake, get a licensed clinician's review, and find out whether this is right for you — before you pay for anything.