Microdosing Semaglutide Rx
A gentler entry point into GLP-1 therapy for appetite regulation and steady weight loss, with a titration schedule set by your response rather than a calendar.
- Appetite regulation that holds
- A gentler on-ramp
- Cardiometabolic benefit
- Flexible monthly plans
- US-licensed pharmacies
- Clinician-guided dosing
- Pause or cancel anytime
Starting at$129 / mo
- HSA / FSA eligible
- Ongoing, expert support
- Free, discreet shipping
- 100% online
- Semaglutide or tirzepatide — which should I pick?
- Tirzepatide's dual-receptor action produces more weight loss on average in head-to-head data, while semaglutide has the longer track record and the cardiovascular outcome trial. Your clinician will weigh both against your history in the intake review.
- How quickly will I notice something?
- Most people notice an appetite change within the first two to three weeks. Scale movement typically lags that by a few weeks.
- Can I drink alcohol on it?
- Many people find their desire for alcohol drops substantially on GLP-1 therapy. There's no absolute prohibition, but alcohol worsens nausea and adds calories that work against the goal.
Nausea, early fullness, constipation and injection-site irritation are most common and typically fade within the first few weeks. Persistent vomiting or severe upper abdominal pain should be reported immediately.
Who this is not for
- Contraindicated with a personal or family history of medullary thyroid carcinoma or MEN 2
- Not for use during pregnancy or while breastfeeding
- May affect absorption of oral medications taken at the same time
- Compounded formulations are not FDA-approved products
Regulatory status: Compounded. Read our full medical disclaimer.
Disclaimer
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. This product is compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Actual product packaging may appear differently than shown.
What is Microdosing Semaglutide?
(sem-a-GLOO-tide)
Semaglutide mimics GLP-1, a hormone your intestine releases after eating, and resists the enzymatic breakdown that clears the natural version within minutes.
The result is a sustained satiety signal: slower gastric emptying, reduced hunger drive, and improved glucose-dependent insulin release.
Individual results vary. Figures shown are modelled from published literature and aggregated, self-reported member check-ins; they are illustrative and are not a guarantee of outcome. See the evidence tier for this treatment.
reported quieter food noise
74%How Microdosing Semaglutide works
Week 1
A quarter-dose start. The first week is about confirming you tolerate it, not about the scale.
30 Days
Appetite changes typically land in weeks two to three. We review side effects before considering any increase.
3 Months
The trend becomes readable. Protein floor and training minimum get checked as closely as the weight.
6 Months
Most patients have found their effective dose by now and hold it rather than continuing to climb.
1 Year and Beyond
Maintenance dosing or a stepped taper, decided together — with a written plan for what happens after.
Our research is shaping what comes next
Most providers in this category focus on doing more. We study what happens when the goal is finding the right amount. With a fully in-house care team, longevity researchers, and 17+ protocols graded by evidence tier, we're built to support the bigger picture of your health.
Once-weekly semaglutide in adults with overweight or obesity
New England Journal of Medicine · 2021
Semaglutide and cardiovascular outcomes in obesity without diabetes
New England Journal of Medicine · 2023
Weight regain after withdrawal of semaglutide
Diabetes, Obesity and Metabolism · 2022
Microdosing Semaglutide
treatment insights
Modelled response patterns are trending in the optimal range
Read our clinical trials
Weight & metabolic and longevity
Our researchers are studying microdosing semaglutide through a longevity-focused lens, exploring how lower-dose protocols may be used in long-horizon care beyond the primary indication.
Read our researchSubscribe & save
Care that starts
with you
$129/month
What's included
- Personalized, clinician-guided plan
- Flexible monthly plans
- Dispensed by a US-licensed pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Third-party potency and sterility testing
How it works
Choosing how you age starts here
- Certified1
Clinician-led
Connect with a clinician
Connect with one of our US-licensed, in-house medical providers with 199+ years of combined clinical experience to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Fast, discreet shipping
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed pharmacy, third-party tested by lot, and shipped to your door in unbranded packaging — cold-chain where the formulation requires it.
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Ongoing support
Adjust as you go
Message your care team whenever something changes. Dose adjustments, side-effect questions and protocol changes are included in your membership — never another appointment, never another fee.
The protocol
- Starting dose
- 0.125–0.25 mg weekly
- Route
- Subcutaneous injection, once weekly
- First check-in
- Day 14
- Titration
- Response-driven, in small increments
- Shipping
- Monthly, cold-chain, discreet packaging
A good fit if
- You want the most-studied option available
- Previous GLP-1 attempts ended because of GI side effects
- You're focused on steady loss rather than the fastest possible result
- You have a metabolic risk factor you want addressed alongside weight
Worth knowing
- Contraindicated with a personal or family history of medullary thyroid carcinoma or MEN 2
- Not for use during pregnancy or while breastfeeding
- May affect absorption of oral medications taken at the same time
- Compounded formulations are not FDA-approved products
Ready when you are
Start Microdosing Semaglutide today
Complete a ten-minute intake, get a licensed clinician's review, and find out whether this is right for you — before you pay for anything.