Microdosing Tirzepatide Rx
A low-dose GLP-1 approach designed to work in sync with the body, which may help minimize side effects, quiet cravings, and support moderate weight loss.
- Quieter food noise
- Fewer side effects than standard dosing
- Steadier, more sustainable loss
- Flexible monthly plans
- US-licensed pharmacies
- Clinician-guided dosing
- Pause or cancel anytime
Starting at$159 / mo
- HSA / FSA eligible
- Ongoing, expert support
- Free, discreet shipping
- 100% online
- How is this different from a standard tirzepatide prescription?
- The molecule is the same. The dosing philosophy is not. Standard protocols escalate on a fixed calendar toward a target dose; we find the lowest dose that changes your appetite signal and hold there as long as it keeps working.
- Will I regain the weight if I stop?
- Some regain is common after stopping any GLP-1. That is exactly why your plan includes a taper and a written maintenance protocol from the start rather than as an afterthought.
- Do I need to inject it myself?
- Yes. It's a small subcutaneous injection once a week, and your kit includes a walkthrough video. Most people find it takes under a minute after the first couple of doses.
Nausea, reduced appetite, constipation, diarrhea and injection-site reactions are the most commonly reported effects, and are generally mildest at microdoses. Severe abdominal pain warrants stopping the medication and contacting your clinician immediately.
Who this is not for
- Not for anyone with a personal or family history of medullary thyroid carcinoma or MEN 2
- Not for use during pregnancy or while breastfeeding
- Requires disclosure of any history of pancreatitis or gallbladder disease
- Compounded formulations are not FDA-approved products
Regulatory status: Compounded. Read our full medical disclaimer.
Disclaimer
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. This product is compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Actual product packaging may appear differently than shown.
What is Microdosing Tirzepatide?
(tir-ZEP-uh-tide)
Tirzepatide activates two incretin receptors — GLP-1 and GIP — that your gut already uses to signal fullness after a meal.
Activating both slows gastric emptying, increases satiety signaling in the hypothalamus, and improves insulin sensitivity in a way that single-receptor drugs do not fully replicate.
Individual results vary. Figures shown are modelled from published literature and aggregated, self-reported member check-ins; they are illustrative and are not a guarantee of outcome. See the evidence tier for this treatment.
noticed moderate weight loss
80%How Microdosing Tirzepatide works
Week 1
Because microdosing begins below standard dosing, the body may have time to adjust gradually with milder side effects for some.
30 Days
Most people describe the first real change here — the constant background negotiation with food gets quieter, and portions settle on their own.
3 Months
Steady, unspectacular loss is the goal. We check that protein intake and resistance training are holding, because that's what protects lean mass.
6 Months
Your clinician reviews whether the dose is still doing work. Many people hold at the same microdose the whole way through.
1 Year and Beyond
We start planning the taper and the maintenance protocol — written down in advance, not improvised on the day you stop.
Our research is shaping what comes next
Most providers in this category focus on doing more. We study what happens when the goal is finding the right amount. With a fully in-house care team, longevity researchers, and 17+ protocols graded by evidence tier, we're built to support the bigger picture of your health.
Tirzepatide once weekly for the treatment of obesity
New England Journal of Medicine · 2022
Dual GIP and GLP-1 receptor agonism in type 2 diabetes
The Lancet · 2021
Lean mass preservation during incretin-based weight loss
Obesity Reviews · 2024
Microdosing Tirzepatide
treatment insights
Modelled response patterns are trending in the optimal range
Read our clinical trials
Weight & metabolic and longevity
Our researchers are studying microdosing tirzepatide through a longevity-focused lens, exploring how lower-dose protocols may be used in long-horizon care beyond the primary indication.
Read our researchSubscribe & save
Care that starts
with you
$159/month
What's included
- Personalized, clinician-guided plan
- Flexible monthly plans
- Dispensed by a US-licensed pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Third-party potency and sterility testing
How it works
Choosing how you age starts here
- Certified1
Clinician-led
Connect with a clinician
Connect with one of our US-licensed, in-house medical providers with 199+ years of combined clinical experience to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Fast, discreet shipping
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed pharmacy, third-party tested by lot, and shipped to your door in unbranded packaging — cold-chain where the formulation requires it.
- 3
Ongoing support
Adjust as you go
Message your care team whenever something changes. Dose adjustments, side-effect questions and protocol changes are included in your membership — never another appointment, never another fee.
The protocol
- Starting dose
- 0.5–1.25 mg weekly
- Route
- Subcutaneous injection, once weekly
- First check-in
- Day 14
- Titration
- Only on clinical indication
- Shipping
- Monthly, cold-chain, discreet packaging
A good fit if
- BMI of 27 or above, or 25+ with a metabolic risk factor
- You want a slower, more tolerable path than standard titration
- You've stopped a GLP-1 before because of side effects
- You're willing to hold a protein and resistance-training floor
Worth knowing
- Not for anyone with a personal or family history of medullary thyroid carcinoma or MEN 2
- Not for use during pregnancy or while breastfeeding
- Requires disclosure of any history of pancreatitis or gallbladder disease
- Compounded formulations are not FDA-approved products
Ready when you are
Start Microdosing Tirzepatide today
Complete a ten-minute intake, get a licensed clinician's review, and find out whether this is right for you — before you pay for anything.